Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.
نویسندگان
چکیده
منابع مشابه
Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.
T cell cytokines are known to play a major role in determining protection and pathology in infectious disease. It has recently become clear that IL-12 is a key inducer of the type 1 T cell cytokine pattern characterized by production of IFN-gamma. Conversely, IL-10 down-regulates IL-12 production and type 1 cytokine responses. We have investigated whether IL-12 and IL-10 might be involved in a ...
متن کاملDifferential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro.
Antigen-presenting cells are thought to modulate the development of Th1 and Th2 cells by the secretion of interleukin-10 (IL-10) and IL-12. Because glucocorticoids (GC) favor the development of Th2 responses, we determined whether dexamethasone (DEX) and hydrocortisone (HC) have differential effects on lipopolysaccharide-induced IL-10 and IL-12 production in whole-blood cultures. Significant in...
متن کاملInterleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
Interleukin (IL)-4 is known to be the most potent cytokine that can initiate Th2 cell differentiation. Paradoxically, IL-4 instructs dendritic cells (DCs) to promote Th1 cell differentiation. We investigated the mechanisms by which IL-4 directs CD4 T cells toward the Th1 cell lineage. Our study demonstrates that the IL-4-mediated induction of Th1 cell differentiation requires IL-10 production b...
متن کاملThe frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis
ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...
متن کاملMODULATION OF INTERLEUKIN-1Β (IL-1Β ), TUMOR NECROSIS FACTOR–Α (TNF-Α) AND INTERLEUKIN-10 (IL-10 ) GENES EXPRESSION FOLLOWING CONCURRENT TRAINING IN WOMEN WITH TYPE2 DIABETES
Background: The purpose of this study was to investigate the effect of concurrent training on pre-inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-10) cytokines gene expression in women with type2 diabetes. Methods: 18-patients (age30-38, >130 glycemic index) were selected, randomly, and divided into control (n=6) the concurrent training(diabetes, n=6) and the concurrent training (healthy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1996
ISSN: 0021-9738
DOI: 10.1172/jci118650